Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Investigating tendon fascicle structure-function relationships in a transgenic-age mouse model using multiple

Paul S Robinson1, Tony W Lin, Abbas F Jawad

  • 1McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA 19104-6081, USA.

Annals of Biomedical Engineering
|August 10, 2004
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cluster-randomized trial of Homework, Organization, and Planning Skills program compared to treatment as usual/waitlist for youth ages 11-14: Study protocol for conceptual replication.

PloS one·2026
Same author

Stage-Specific Collagen V Knockdown Reveals Temporal Control of Fibrillogenesis, Remodeling, and Mechanics in Tendon Healing.

International journal of molecular sciences·2026
Same author

Loss of type III collagen has limited effect on tendon healing in young adult mice.

Matrix biology : journal of the International Society for Matrix Biology·2026
Same author

Spontaneous Leg Movements Measured by Wearable Sensors in Infancy Differentiate Later Risk for Cerebral Palsy.

Pediatric neurology·2026
Same author

Performance outcomes of the PEDI-CAT for assessing functional ability in the population with leukodystrophy.

Developmental medicine and child neurology·2026
Same author

Tendon-Targeted Knockout of Collagen XII Disrupts Murine Achilles Tendon Structure, Function, and Gene Expression at Later Stages of Postnatal Development.

Annals of biomedical engineering·2026

Glycosaminoglycan (GAG) content is the primary driver of tendon mechanical properties, influencing both direct function and indirectly affecting collagen structure. This finding is crucial for developing effective tissue engineering strategies for tendon repair.

Area of Science:

  • Biomaterials Science
  • Orthopedic Research
  • Tissue Engineering

Background:

  • Tendon and ligament repair necessitates engineered tissues with native mechanical properties.
  • Quantitative data on the specific roles of tendon components in function is limited.
  • Previous studies used univariate analyses, failing to capture complex structure-function relationships.

Purpose of the Study:

  • To quantitatively assess the independent and combined contributions of seven structural and compositional variables to tendon mechanical properties.
  • To utilize multiple regression models for a comprehensive analysis of tendon fascicle mechanics.
  • To establish a predictive model for tissue mechanical properties based on structural and compositional factors.

Main Methods:

  • Analysis of tail tendon fascicles from transgenic mouse models.

Related Experiment Videos

  • Inclusion of structural, biochemical, and mechanical assessments.
  • Application of multiple regression statistical models to evaluate variable contributions.

    • Main Results:

    • Glycosaminoglycan (GAG) content emerged as the strongest predictor of mechanical properties.
    • GAG content showed significant correlations with collagen content and mean collagen fibril diameter.
    • Collagen fibril area fraction significantly predicted only material properties within the multivariate model.

    Conclusions:

    • GAG content plays a pivotal role in determining tendon mechanical properties, acting both directly and indirectly through collagen characteristics.
    • The findings provide critical insights for the design of functional engineered tendons.
    • Multivariate analysis reveals the complex interplay of structural and compositional factors in tendon biomechanics.