Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional tissue engineering of chondral and osteochondral constructs.

Eric G Lima1, Robert L Mauck, Shelley H Han

  • 1Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.

Biorheology
|August 10, 2004
PubMed
Summary

Developing an articular cartilage substitute is crucial for osteoarthritis treatment. Finite element modeling revealed that osteochondral constructs exhibit inhomogeneous mechanical signals, potentially aiding engineered tissue development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Silk Ionomer-Based Modular Nanocoatings for Potential Immuno-Regenerative Cell Therapy in Osteoarthritis.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Social and Demographic Health Disparities in Knee Osteoarthritis and Total Knee Arthroplasty.

Arthroplasty today·2026
Same author

Intrinsic Viscoelasticity of Type II Collagen Contributes to the Viscoelastic Response of Immature Bovine Articular Cartilage Under Unconfined Compression Stress Relaxation.

Journal of biomechanical engineering·2026
Same author

Synovial fluid protects cartilage against fatigue failure in cyclical compression.

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft·2025
Same author

Toward Lesion-specific Stenting Strategies: A Computational Framework to Validate the Deployment of Balloon-expandable Stents.

Annals of biomedical engineering·2025
Same author

The Negative Impact of High Molecular Weight Hyaluronan on Anterior Cruciate Ligament Wound Repair.

The journal of knee surgery·2025

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Orthopedic Surgery

Background:

  • Osteoarthritis (OA) and articular cartilage damage necessitate effective cartilage substitutes.
  • Articular cartilage's poor healing capacity and complex function pose challenges for tissue engineering.
  • Previous work enhanced chondrocyte-seeded agarose constructs' mechanical properties via mechanical loading.

Purpose of the Study:

  • To develop and analyze osteochondral constructs for articular cartilage repair.
  • To investigate the mechanical environment within engineered osteochondral constructs using finite element modeling (FEM).
  • To guide the optimization of mechanical loading for functional tissue engineering of cartilage substitutes.

Main Methods:

  • Developed a technique for creating gel constructs integrated with a bony substrate (osteochondral constructs).

Related Experiment Videos

  • Utilized finite element modeling (FEM) to predict stress, strain, and fluid flow fields.
  • Subjected constructs to dynamic deformational loading in simulations.

    • Main Results:

    • Osteochondral constructs showed inhomogeneous mechanical signal distribution, unlike homogenous chondral constructs.
    • The predicted inhomogeneous mechanical environment may promote differential development within engineered tissues.
    • FEM results provide insights into the mechanical cues experienced by engineered osteochondral constructs.

    Conclusions:

    • FEM is a valuable tool for predicting mechanical environments in engineered osteochondral constructs.
    • Inhomogeneous mechanical signals in osteochondral constructs may be beneficial for tissue development.
    • This modeling approach will guide future experimental optimization of mechanical loading for articular cartilage regeneration.