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Post-stroke depression: research methodology of a large multicentre observational study (DESTRO)
V Toso1, C Gandolfo, S Paolucci
1Division of Neurology, S. Bortolo Hospital, Vicenza, Italy. vito.toso@ulssvicenza.it
Summary
Post-stroke depression (PSD) affects many individuals, with prevalence noted at 33.6% within six months. This study explores PSD
Area of Science:
- Neurology
- Psychiatry
- Epidemiology
Background:
- Post-stroke depression (PSD) is a common complication with heterogeneous reported prevalence.
- Existing data on PSD onset, evolution, and impact is limited, necessitating further research.
Purpose of the Study:
- To investigate the prevalence, onset, and evolution of post-stroke depression (PSD) in a large Italian cohort.
- To analyze the correlation of PSD with clinical stroke characteristics, functional status, cognition, and quality of life.
Main Methods:
- A multicenter observational study (DESTRO) involving 53 Italian neurology centers from 2000-2003.
- Involved registration of 6289 stroke patients, selection of 1817, enrollment of 1074, and 2-year follow-up of 1064 patients.
- Mood assessment using DSM IV criteria, Beck Depression Inventory, and Montgomery-Asberg Depression Rating Scale; functional and cognitive assessments included Barthel Index, modified Rankin Scale, and MMSE.
Main Results:
- Preliminary data indicates a PSD prevalence of 33.6% within the first six months post-stroke.
- The study aims to provide comprehensive data on PSD prevalence, onset, and evolution.
- Analysis will correlate PSD with functional outcomes, cognitive function, and quality of life.
Conclusions:
- The DESTRO study is a large-scale, longitudinal investigation providing crucial insights into PSD.
- Findings are expected to elucidate the relationship between PSD and the functional and clinical consequences of stroke.
- This research will contribute valuable data to understanding and managing post-stroke depression.