Related Experiment Video
Updated: Aug 23, 2026

Employing Transcranial Magnetic Stimulation in a Resource Limited Environment to Establish Brain-Behavior Relationships
Published on: April 20, 2022
A replication study of the neural correlates of deception
Frank Andrew Kozel1, Tamara M Padgett, Mark S George
1Center for Advanced Imaging Research and the Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA. kozelfa@musc.edu
Abstract:
The authors attempted to replicate prior group brain correlates of deception and improve on the consistency of individual results. Healthy, right-handed adults were instructed to tell the truth or to lie while being imaged in a 3T magnetic resonance imaging (MRI) scanner. Blood oxygen level-dependent functional MRI significance maps were generated for subjects giving a deceptive answer minus a truthful answer (lie minus true) and the reverse (true minus lie). The lie minus true group analysis (n = 10) revealed significant activation in 5 regions, consistent with a previous study (right orbitofrontal, inferior frontal, middle frontal cortex, cingulate gyrus, and left middle frontal), with no significant activation for true minus lie. Individual results of the lie minus true condition were variable. Results show that functional MRI is a reasonable tool with which to study deception.
Related Concept Videos
Understanding Deception
Nonconscious Mimicry
Deindividuation
Facial Feedback Hypothesis
False Memories
One primary source of false memories is misattribution, where individuals incorrectly associate external information with...
Ethics in Research

