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Related Experiment Videos

FOXP2 and the mirror system.

Michael C Corballis1

  • 1Department of Psychology, University of Auckland, Private Bag 92019, Auckland 1, New Zealand. mcorballis@myrealbox.com

Trends in Cognitive Sciences
|August 11, 2004
PubMed
Summary

A mutation in the forkhead box P2 (FOXP2) gene causes inherited speech deficits. This is linked to underactivity in Broca's area, suggesting a connection to the mirror-neuron system and speech evolution.

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Area of Science:

  • Neurogenetics
  • Evolutionary Neuroscience
  • Speech and Language Sciences

Background:

  • An inherited deficit in spoken language is linked to the forkhead box P2 (FOXP2) gene.
  • The FOXP2 gene is located on chromosome 7.

Purpose of the Study:

  • To investigate the neural underpinnings of inherited speech deficits.
  • To explore the potential link between FOXP2, Broca's area, and the mirror-neuron system.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to study brain activity during word generation.
  • The study examined individuals with inherited speech deficits associated with FOXP2 mutations.

Main Results:

  • Underactivity in Broca's area was observed during word generation in individuals with the FOXP2 mutation.
  • This finding suggests a potential connection between FOXP2 and the mirror-neuron system in the primate homologue of Broca's area.

Conclusions:

  • The FOXP2 gene may play a crucial role in the function of Broca's area.
  • This link has implications for understanding the evolution of Broca's area and its role in speech production.

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