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Published on: May 15, 2019
Thalidomide-induced amenorrhea: case report and literature review
Sejal P Dharia1, Michael P Steinkampf, Cynthia Cater
1Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 619 19th Street South, Birmingham, AL 35249, USA. sdharia@uabmc.edu
Objective:
To report on a patient with thalidomide-induced amenorrhea and review the literature on the effect of thalidomide on ovarian function.
Design:
Case report and literature review.
Setting:
University medical center.
Patient(S):
A twenty-eight-year-old woman referred for a 2-year history of amenorrhea.
Intervention(S):
History, physical examination, laboratory evaluation of the patient, and subsequent medical therapy. Literature review performed by using OVID/Medline and PubMed search strategies.
Main Outcome Measure(S):
Diagnosis and appropriate management of thalidomide-induced amenorrhea.
Result(S):
Elevated pituitary gonadotropins, other labs normal. All known causes of hypergonadotropic amenorrhea were excluded.
Conclusion(S):
Thalidomide induces hypergonadotropic amenorrhea. Although this effect appears to be reversible, the long-term effect of thalidomide on ovarian reserve is unclear.
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