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Pustular psoriasis induced by infliximab
Marzieh Thurber1, Adrienne Feasel, John Stroehlein
1University of Texas Houston Medical School, Houston, USA.
Journal of Drugs in Dermatology : JDD
|August 12, 2004
Summary
Pustular psoriasis, a rare skin condition, can paradoxically emerge during treatment with infliximab, an immunobiologic drug. Further research is needed to understand this reaction and infliximab
Area of Science:
- Dermatology
- Immunology
- Gastroenterology
Background:
- Pustular psoriasis is a rare variant of psoriasis.
- Immunobiologic agents, like infliximab, show efficacy in treating pustular psoriasis.
- Infliximab is commonly used for chronic ulcerative colitis.
Observation:
- A patient receiving infliximab for chronic ulcerative colitis developed pustular psoriasis.
- The patient exhibited cutaneous and pathological changes consistent with pustular psoriasis.
Findings:
- This case presents a paradoxical reaction to infliximab treatment.
- Pustular psoriasis developed despite infliximab therapy.
Implications:
- Long-term studies are required to understand this paradoxical reaction.
- Further investigation into the mechanism of action and side effect profiles of infliximab is necessary.
- Understanding these reactions is crucial for optimizing immunobiologic therapies.