Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Conserved molecular program regulating cranial and appendicular skeletogenesis.

B Frank Eames, Jill A Helms

    Developmental Dynamics : an Official Publication of the American Association of Anatomists
    |August 12, 2004
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Arylsulfatase I is a novel lysosomal chondroitin endosulfatase regulating endochondral ossification.

    Matrix biology : journal of the International Society for Matrix Biology·2026
    Same author

    Soft-Tissue Integration of Dental Implants: Formation, Maintenance, and Relevance for Peri-Implant Health.

    Journal of periodontal research·2026
    Same author

    fam20b-dependent proteoglycans do not affect dermal bone formation and fin regeneration, but Bmp signalling promotes fin regenerate outgrowth.

    Differentiation; research in biological diversity·2025
    Same author

    The holocephalan ratfish endoskeleton shares trabecular and areolar mineralization patterns, but not tesserae, with elasmobranchs little skate and catshark.

    eLife·2025
    Same author

    Oxidative stress-induced intervertebral disc remodelling and elevated stiffness drive idiopathic scoliosis in preclinical models.

    Nature communications·2025
    Same author

    Multiscale, interspecies evaluation of parameters affecting alveolar bone repair.

    Journal of periodontology·2025
    Same journal

    Multi-stage transcriptome analysis reveals genetic orchestration of rat testis development.

    Developmental dynamics : an official publication of the American Association of Anatomists·2026
    Same journal

    Three-dimensional observation of the muscle-tendon integration process in mouse embryos.

    Developmental dynamics : an official publication of the American Association of Anatomists·2026
    Same journal

    Goofy/123Cre lineage tracing differentiates olfactory and vomeronasal neurons from GnRH-1 and terminal nerve neurons during neuronal migration and reveals additional olfactory placode-derived cells in the brain.

    Developmental dynamics : an official publication of the American Association of Anatomists·2026
    Same journal

    Prenatal sexual dimorphism in human pelvic tilt at the onset of fetal ossification.

    Developmental dynamics : an official publication of the American Association of Anatomists·2026
    Same journal

    Meet the editorial team. An interview with Ralph Marcucio, Assistant Editor, University of California San Francisco, United States.

    Developmental dynamics : an official publication of the American Association of Anatomists·2026
    Same journal

    Editorial highlights.

    Developmental dynamics : an official publication of the American Association of Anatomists·2026
    See all related articles

    Skeletal development in chick limbs and heads shares fundamental gene expression patterns for cell differentiation. Subtle differences in signaling pathways may influence cranial versus appendicular bone and cartilage formation.

    Area of Science:

    • Developmental Biology
    • Skeletal Biology
    • Genetics

    Background:

    • Appendicular skeleton is commonly used for bone and cartilage differentiation studies.
    • Assumption of uniform skeletal formation across the body persists despite varied precursor origins.
    • Investigating conserved gene regulatory mechanisms in skeletal development is crucial.

    Purpose of the Study:

    • To test if a core set of genes directs skeletal cell differentiation throughout the body.
    • To compare gene expression in chick limb and head skeletal development.
    • To identify conserved and distinct molecular markers in different skeletal elements.

    Main Methods:

    • Analysis of transcription factor expression in early skeletogenic condensations (limb and head).
    • Comparison of mature cartilage and bone tissues using histological and molecular markers.

    Related Experiment Videos

  • Examination of skeletal collagens and signaling molecules in chick embryos.

    • Main Results:

    • Similar transcription factor expression patterns observed in limb and head skeletogenic condensations undergoing endochondral ossification.
    • Unique transcription factor expression patterns identified for three distinct skeletal tissue fates.
    • Vasculature exclusion observed in all analyzed skeletogenic condensations.
    • Generally conserved histological and molecular markers between limb and head skeletal tissues.
    • Subtle differences in signaling pathways noted between cranial and appendicular skeletogenesis.

    Conclusions:

    • A fundamental set of genes likely directs skeletal cell differentiation across different body regions.
    • Distinct molecular signatures differentiate skeletal tissue fates.
    • While largely conserved, specific signaling pathways may contribute to cranial-appendicular skeletal differences.