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Updated: Aug 23, 2026
An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
Published on: July 28, 2012
One immediate postoperative instillation of chemotherapy in low risk Ta, T1 bladder cancer patients. Is it always
J R Oddens1, A P M van der Meijden, R Sylvester
1Department of Urology, Jeroen Bosch Hospital, 's Hertogenbosch, The Netherlands. oddens@hotmail.com
Objective:
The optimal treatment for solitary low grade, low stage papillary bladder tumours consists of transurethral resection (TUR) followed by one immediate postoperative instillation with a chemotherapeutic drug. However, when during TUR a bladder perforation or a near-perforation occurs, instillation of a chemotherapeutic drug may lead to leakage outside the bladder, possibly causing severe morbidity. So far, few case reports dealing with complications using mitomycin C have been published, but severe complications of leakage after an early adjuvant instillation with epirubicin have not been reported.
Methods:
We describe 3 patients in whom we observed serious complications of one immediate postoperative instillation of epirubicin.
Results:
Two of the patients recovered after conservative therapy, one patient died due to multi organ failure after explorative laparotomy.
Conclusion:
In order to prevent such complications, an immediate postoperative instillation has to be avoided when there is overt or even suspicion of bladder wall perforation.
