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Mean platelet volume and exercise stress test.
Mehmet Birhan Yilmaz1, Ersin Saricam, Senay Funda Biyikoglu
1Yuksek Ihtisas Hospital, Cardiology Clinic, Sihhiye, Ankara, Turkey. cardioceptor@ttnet.net.tr
Journal of Thrombosis and Thrombolysis
|August 13, 2004
Summary
Acute exercise transiently activates the thrombotic system. Patients with coronary artery disease show increased mean platelet volume (MPV) post-exercise, indicating heightened thrombotic risk, unlike healthy individuals.
Area of Science:
- Cardiology
- Exercise Physiology
- Hematology
Background:
- Regular physical activity reduces cardiovascular disease risk.
- Acute exercise transiently activates the thrombotic system.
- Patients with ischemic heart disease may have reduced fibrinolytic capacity, increasing risk during exertion.
Purpose of the Study:
- To investigate the effect of exercise on platelet activation in patients with coronary artery disease.
- To compare changes in mean platelet volume (MPV) after exercise in patients versus controls.
Main Methods:
- Treadmill exercise tests (TMET) were performed on 63 patients with significant coronary artery disease and 35 controls.
- Mean platelet volume (MPV) was measured before and 30 minutes after TMET.
- Coronary angiography confirmed significant coronary artery disease in the patient group.
Main Results:
- Pre-exercise MPV was similar in both patient and control groups.
- Post-exercise, MPV significantly increased in patients with coronary artery disease (p < 0.001).
- No significant MPV increase was observed in the control group after exercise (p = 0.379).
Conclusions:
- Exercise may increase thrombotic event susceptibility in coronary artery disease patients via platelet activation, indicated by rising MPV.
- Healthy individuals compensate with increased fibrinolytic capacity.
- Patients with ischemic heart disease may face higher risks of acute ischemic events following exercise.