Related Experiment Video
Updated: Aug 13, 2026
16:19
High Throughput Single-cell and Multiple-cell Micro-encapsulation
Published on: June 15, 2012
Coencapsulation of three different guests in a cylindrical host
1The Skaggs Institute for Chemical Biology, Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Chemical Communications (Cambridge, England)
|August 13, 2004
Summary
Researchers screened anion and organic solvent combinations to create encapsulation complexes. These complexes successfully enclosed three distinct guest molecules within their structure.
Area of Science:
- Supramolecular Chemistry
- Materials Science
Background:
- Supramolecular chemistry focuses on non-covalent interactions to create complex molecular assemblies.
- Encapsulation complexes are vital for molecular recognition, drug delivery, and catalysis.
Purpose of the Study:
- To explore novel combinations of anions and organic solvent molecules for complex formation.
- To develop efficient encapsulation strategies for multiple guest molecules.
Main Methods:
- Screening of various anion and organic solvent combinations.
- Characterization of the resulting encapsulation complexes.
- Assessment of guest molecule inclusion within the complexes.
Main Results:
- Identified specific combinations of anions and organic solvents that form stable encapsulation complexes.
- Demonstrated the successful encapsulation of three different guest molecules simultaneously.
- The developed complexes exhibited selective binding properties.
Conclusions:
- The study successfully demonstrated the formation of novel encapsulation complexes using tailored anion-organic solvent systems.
- These findings open avenues for designing advanced host-guest systems with potential applications in molecular storage and separation.
Related Concept Videos
01:46Eukaryotic Compartmentalizations
One of the distinguishing features of eukaryotic cells is that they contain membrane-bound organelles, such as the nucleus and mitochondria, that carry out specialized functions. Since biological membranes are only selectively permeable to solutes, they help create a compartment with controlled conditions inside an organelle. These microenvironments are tailored to the organelle's specific functions and help isolate them from the surrounding cytosol.
For example, lysosomes in the animal cells...
For example, lysosomes in the animal cells...
00:58Genomic DNA in Eukaryotes
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
00:58DNA Packaging
Overview
02:11Conformations of Cyclohexane
Cyclohexane does not exist in a planar form due to the high angle and torsional strain it would experience in the planar structure. Instead, it adopts non-planar chair and boat conformations.
The chair form is the most stable and derives its name from its resemblance to the “easy chair.” In the chair conformation, two carbon atoms are arranged out-of-plane — one above and one below, minimizing the torsional strain. In the chair form, the bond angle is very close to the ideal tetrahedral value,...
The chair form is the most stable and derives its name from its resemblance to the “easy chair.” In the chair conformation, two carbon atoms are arranged out-of-plane — one above and one below, minimizing the torsional strain. In the chair form, the bond angle is very close to the ideal tetrahedral value,...
02:02Chair Conformation of Cyclohexane
The chair conformation is the most stable form of cyclohexane due to the absence of angle and torsional strain. The absence of angle strain is a result of cyclohexane’s bond angle being very close to the ideal tetrahedral bond angle of 109.5° in its chair conformer. Similarly, the torsional strain is also absent owing to the perfectly staggered arrangement of bonds.
The hydrogen atoms linked to carbons are arranged in two different axial and equatorial orientations to achieve this staggered...
The hydrogen atoms linked to carbons are arranged in two different axial and equatorial orientations to achieve this staggered...
02:33Stereoisomerism of Cyclic Compounds
In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...