Related Experiment Video

Updated: Aug 23, 2026

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model
06:02

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model

Published on: November 6, 2020

Candida endocarditis: contemporary cases from the International Collaboration of Infectious Endocarditis Merged

Daniel K Benjamin1, Jose M Miro, Bruno Hoen

  • 1Department of Pediatrics, Duke University, Durham, NC, USA. danny.benjamin@duke.edu

Scandinavian Journal of Infectious Diseases
|August 17, 2004
PubMed

Insights

Candida infective endocarditis (IE) is a growing concern, often affecting prosthetic valves. This study found a 37% mortality rate in patients with Candida IE, highlighting the need for further research.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Mycology

Background:

  • Candida infective endocarditis (IE) is an emerging clinical challenge.
  • Most available data on Candida IE comes from single-center reviews.
  • The incidence and outcomes of Candida IE require further investigation.

Purpose of the Study:

  • To evaluate the characteristics and outcomes of patients with Candida IE.
  • To compare Candida IE with other forms of IE within a larger cohort.
  • To determine the mortality associated with Candida IE.

Main Methods:

  • Retrospective analysis of a cohort of 2,022 patients with IE.
  • Identification and evaluation of 16 patients diagnosed with Candida IE.
  • Comparison of demographic and clinical features between Candida IE and non-Candida IE groups.

Main Results:

  • Candida IE occurred in 16 patients within a cohort of 2,022 IE patients.
  • Prosthetic valve involvement was significantly more common in Candida IE (50%) compared to non-Candida IE (17%).
  • The overall mortality rate for patients with Candida IE was 37%.

Conclusions:

  • Candida IE is associated with a high mortality rate.
  • Prosthetic valves are a significant risk factor for Candida IE.
  • Further multicenter studies are warranted to better understand and manage Candida IE.

More Related Videos

A Catheter-Related Candida albicans Infection Model in Mouse03:24

A Catheter-Related Candida albicans Infection Model in Mouse

Published on: March 22, 2024

Related Concept Videos

Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...