Related Experiment Video
Updated: Aug 23, 2026
Inducement and Evaluation of a Murine Model of Experimental Myopia
Published on: January 22, 2019
[Effect of time limited form deprivation on the development of myopia in guinea pigs]
Zhen-Ying Cheng1, Jing-Hai Li, Rong Li
1Department of Ophthalmology, Qilu Hospital of Shandong University, Ji'nan 250012, China. zycheng@tom.com
Objective:
To investigate the effect of time limited form deprivation on the development of form-deprived-myopia (FDM) in guinea pigs.
Methods:
Four-week-old guinea pigs (n = 20) were randomly divided into four groups. Group I was used as normal control without any treatment. In group II-IV, unilateral form deprivation was produced with eye patch for 4 weeks. In group II, eye occlusion was fitted continuously. In group III and IV, occlusion was removed each day for 1 or 4 hours. Refractive development was monitored by retinoscopy and A-scan ultrasonography before and after experiment.
Results:
After 4 weeks, varied degree of axial myopia was developed in the groups II and III with eye occlusion. Continuous form deprivation produced -5.49 D of relative myopia and the fellow eyes produced +0.76 D of relative hyperopia. One hour of unrestricted vision was sufficient to reduce the degree of FDM by about 50%. The eyes allowed 4 hours of unrestricted vision did not result in myopia.
Conclusion:
Long periods of form deprivation can be counterbalanced by quite short periods of unrestricted vision.
