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Updated: Jul 24, 2026

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
Published on: July 24, 2021
Principles of use of antibacterial agents
Margaret Trexler Hessen1, Donald Kaye
1Department of Medicine, Drexel University College of Medicine, 3300 Henry Avenue, Philadelphia, PA 19129, USA. mth3940@comcast.net
Abstract:
The selection of an antimicrobial regimen is based on a number of factors, including the nature of the infection, the identity and susceptibility of the pathogens, host characteristics, and the pharmacokinetics and pharmacodynamics of antimicrobial agents. This article provides a comprehensive overview of these factors, with particular attention to pharmacokinetics and monitoring for efficacy and toxicity. A brief summary is also provided of some other topics discussed in detail elsewhere in this issue, such as susceptibility testing, pharmacodynamics, and pharmacokinetics-pharmacodynamics parameters.
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