Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mechanical compression elicits NO-dependent increases in coronary flow.

Dong Sun1, An Huang, Gabor Kaley

  • 1Dept. of Physiology, New York Medical College, Valhalla, NY 10595, USA. Dong_Sun@nymc.edu

American Journal of Physiology. Heart and Circulatory Physiology
|August 17, 2004
PubMed
Summary

Cardiac contraction deforms coronary vessels, stimulating nitric oxide (NO) release and increasing coronary blood flow. This NO-dependent mechanism enhances heart perfusion.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hypoxia-mediated chromatin accessibility reprogramming of CA9 induces treatment resistance in colorectal mucinous adenocarcinoma.

Journal of gastroenterology·2026
Same author

Network meta-analysis of bisphosphonates in the treatment of bone metastases from breast cancer.

International journal of clinical pharmacology and therapeutics·2026
Same author

Integrative Proteogenomic Characterization of Left-Sided and Right-Sided Colorectal Cancer.

MedComm·2026
Same author

Global Trends and Research Hot Spots in Medication Regimen Simplification: Bibliometric Analysis.

JMIR aging·2026
Same author

Rhodium/Bisphosphine-Thiourea System Catalyzed Asymmetric Hydrogenation of α,β-Unsaturated γ-Lactams.

Organic letters·2026
Same author

FGFR2-responsive self-assembled hydrogel releases its inhibitor to suppress the progression of endometriosis.

Journal of controlled release : official journal of the Controlled Release Society·2026

Area of Science:

  • Cardiovascular Physiology
  • Endothelial Function
  • Nitric Oxide Biology

Background:

  • Endothelial deformation is known to trigger nitric oxide (NO) release.
  • Cardiac contraction causes mechanical stress on coronary vessels.

Purpose of the Study:

  • To investigate if cardiac contraction-induced coronary vessel deformation releases NO and increases coronary flow.
  • To elucidate the role of NO in mediating compression-induced coronary hyperemia.

Main Methods:

  • Langendorff-perfused rat hearts were subjected to extracardiac compression to simulate cardiac contraction.
  • Coronary flow, nitrite levels, and endothelial NO synthase phosphorylation were measured.
  • Nitric oxide synthesis inhibition was used to assess NO's role.

Related Experiment Videos

Main Results:

  • Extracardiac compression significantly increased coronary flow and nitrite release.
  • Increased phosphorylation of endothelial NO synthase was observed.
  • Inhibition of NO synthesis abolished the compression-induced coronary flow increase.

Conclusions:

  • Cardiac contraction-induced coronary vascular deformation stimulates NO release from the endothelium.
  • This NO release leads to increased coronary blood flow, a novel mechanism for enhanced cardiac perfusion.