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Radiological sacroiliitis, a hallmark of spondylitis, is linked with CARD15 gene polymorphisms in patients with

H Peeters1, B Vander Cruyssen, D Laukens

  • 1Department of Gastroenterology, Ghent University Hospital, Ghent, Belgium. harald.peeters@UGent.be

Annals of the Rheumatic Diseases
|August 17, 2004
PubMed

Insights

Genetic variants in the CARD15 gene are linked to sacroiliitis, an inflammatory condition affecting the spine in Crohn's disease patients. This finding highlights CARD15 as a predictor for this extraintestinal manifestation.

Area of Science:

  • Gastroenterology and Immunology
  • Genetics and Molecular Biology

Background:

  • Sacroiliitis is a frequent extraintestinal manifestation in Crohn's disease (CD).
  • The association between sacroiliitis and HLA-B27 is less clear, while CARD15 gene polymorphisms are linked to CD susceptibility, particularly ileal, fibrostenosing, and familial forms.

Purpose of the Study:

  • To determine if CARD15 gene polymorphisms are associated with sacroiliitis in patients diagnosed with Crohn's disease.

Main Methods:

  • 102 Crohn's disease patients underwent clinical evaluation and sacroiliac joint radiography.
  • CARD15 gene polymorphisms were genotyped using RFLP-PCR and direct sequencing.
  • HLA-B27 phenotype was assessed.

Main Results:

  • Twenty-three percent of patients showed radiological evidence of sacroiliitis; only three were HLA-B27 positive.
  • A significant association was found between sacroiliitis and CARD15 variants (78% vs. 48%, p=0.01).
  • Multivariate analysis confirmed that the association between sacroiliitis and CARD15 polymorphisms was independent of other CD phenotypes.

Conclusions:

  • CARD15 variants are identified as genetic predictors for Crohn's disease-related sacroiliitis.
  • A significant association exists between CARD15 polymorphisms and this extraintestinal manifestation of Crohn's disease.
Abstract

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