Related Experiment Video

Updated: Jul 17, 2026

Transuterine Fetal Tracheal Occlusion Model in Mice
06:31

Transuterine Fetal Tracheal Occlusion Model in Mice

Published on: February 5, 2021

Does Down syndrome affect the outcome of congenital duodenal obstruction?

M V A Singh1, C Richards, J C Bowen

  • 1Department of Paediatric Surgery, Royal Manchester Children's Hospital, Hospital Road, Pendlebury, Manchester M27 4HA , UK. mvasingh@hotmail.com

Pediatric Surgery International
|August 17, 2004
PubMed

Insights

Congenital duodenal obstruction (DO) in children with Down syndrome (DS) shows similar postoperative outcomes but a higher rate of cardiac defects. DS does not impact DO morbidity or mortality.

Area of Science:

  • Pediatric Surgery
  • Clinical Genetics
  • Neonatology

Background:

  • Congenital duodenal obstruction (DO) is frequently associated with Down syndrome (DS) and other congenital anomalies.
  • Previous studies have not fully elucidated the impact of DS on the spectrum of malformations and postoperative outcomes in DO patients.

Purpose of the Study:

  • To investigate the influence of Down syndrome on associated congenital malformations and postoperative morbidity and mortality in infants with congenital duodenal obstruction.

Main Methods:

  • Retrospective analysis of 79 infants with congenital duodenal obstruction over an 11-year period.
  • Patients were divided into two groups: those with DS (n=28) and those without DS (n=51).
  • Comparison of gestational age, birth weight, incidence of coexisting malformations, time to full feeds, complications, and mortality between groups.

Main Results:

  • No significant differences were observed in gestational age, birth weight, time to full feeds, or postoperative complications between the DS and non-DS groups.
  • Congenital malformations were present in 68% of patients; gastrointestinal anomalies were most common in the non-DS group, while cardiac anomalies predominated in the DS group (81.5%).
  • Mortality rates did not differ significantly between groups, though delayed mortality in the DS group was linked to cardiac and respiratory conditions.

Conclusions:

  • Down syndrome does not significantly influence the short-term morbidity and mortality associated with congenital duodenal obstruction.
  • Infants with Down syndrome and duodenal obstruction have a notably higher incidence of congenital cardiac abnormalities.
  • Coexisting cardiac and respiratory diseases are significant factors in delayed mortality for infants with Down syndrome and duodenal obstruction.

More Related Videos

Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice08:50

Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice

Published on: October 18, 2024

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells06:38

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells

Published on: March 7, 2025

Related Concept Videos

Meiosis I01:49

Meiosis I

Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by a...
Sex-linked Disorders01:43

Sex-linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
Nondisjunction01:29

Nondisjunction

During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
Meiosis vs. Mitosis02:57

Meiosis vs. Mitosis

Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Pyloric Obstruction01:11

Pyloric Obstruction

Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
Intestinal Obstruction II: Pathophysiology01:07

Intestinal Obstruction II: Pathophysiology

Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...