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Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
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Early and subtle abnormalities of left ventricular function in clinically stable coronary artery disease patients

R Bolognesi1, D Tsialtas, R Zeppellini

  • 1Cattedra di Cardiologia, Università degli Studi di Parma, Parma, Italy.

Journal of Cardiac Failure
|August 17, 2004
PubMed

Insights

Early ischemic cardiomyopathy shows subtle systolic and diastolic dysfunction in coronary artery disease patients with normal ejection fraction, indicating potential for early detection.

Area of Science:

  • Cardiology
  • Cardiovascular Physiology

Background:

  • Ischemic cardiomyopathy's initial phase may present early left ventricular (LV) function alterations during relaxation.
  • Detecting precocious abnormalities in both LV systolic and diastolic phases is crucial for early intervention.

Purpose of the Study:

  • To identify early systolic and diastolic abnormalities in patients with coronary artery disease (CAD) and normal LV ejection fraction.

Main Methods:

  • Simultaneous left ventricular catheterization and echo-Doppler techniques were employed.
  • Systolic and diastolic functions were assessed in 44 stable CAD patients with normal ejection fraction and 9 controls.

Main Results:

  • CAD patients exhibited significantly prolonged E deceleration time, tau, and elevated LV end-diastolic volume and pressure.
  • LV end-systolic volume and lowest diastolic pressure were higher, while mean dP/dt/P values were lower in CAD patients compared to controls.
  • A strong correlation was observed between dP/dt/P, tau, and LV pressures in all subjects.

Conclusions:

  • Subtle abnormalities in systolic and diastolic function parameters are detectable in most CAD patients with preserved ejection fraction.
  • These findings suggest that early detection of cardiac dysfunction is possible even before significant ejection fraction decline.
Abstract

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