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Published on: January 3, 2013
Expression of Survivin in pancreatic cancer and its correlation to expression of Bcl-2
Jian-Guo Qiao1, Yu-Qing Zhang, Yu-Chun Yin
1Department of General Surgery, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, China.
Aim:
To investigate the expression of Survivin in pancreatic cancer and its correlation to the expression of Bcl-2.
Methods:
Survivin and Bcl-2 expressions were examined by immunohistochemistry in 42 tissue samples from pancreatic cancer and 10 from normal pancrease.
Results:
No survivin expression was detected in the tissue samples from normal pancrease, while it was detected in 34 of 42 tissue samples from pancreatic cancer (81.95%). There was a correlation between survivin expression and differentiation and stages of pancreatic cancer. Survivin positive cases were strongly correlated to Bcl-2 expression (28/30 vs 6/12, P<0.05).
Conclusion:
Overexpression of survivin plays an important role in the development and progression of pancreatic cancer, and correlates to the expression of Bcl-2. Survivin expression can be used as a prognostic factor.
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