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Pulse wave velocity and ankle brachial index in patients with Kawasaki disease

Reiki Ooyanagi1, Shigeto Fuse, Hideshi Tomita

  • 1Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan.

Pediatrics International : Official Journal of the Japan Pediatric Society
|August 18, 2004
PubMed

Insights

Children with a history of Kawasaki disease (KD) may experience increased aortic stiffness. This study found higher pulse wave velocity (PWV) in KD patients compared to controls, suggesting potential long-term vascular effects.

Area of Science:

  • Cardiovascular Research
  • Pediatric Cardiology
  • Vascular Health

Background:

  • Kawasaki disease (KD) is a pediatric illness that can affect systemic arteries.
  • Atherosclerosis risk factors in KD survivors are not well-established.
  • Pulse wave velocity (PWV) and ankle-brachial index (ABI) assess arterial stiffness and atherosclerosis.

Purpose of the Study:

  • To investigate arterial stiffness (PWV) and atherosclerosis (ABI) in patients with a history of Kawasaki disease.
  • To compare vascular parameters in KD patients with a control group.

Main Methods:

  • Studied 90 patients with a history of KD (age 4-25) and 119 controls.
  • Measured PWV and ABI, defining high PWV as >/=120% of normal and low ABI as
  • Analyzed data using t-tests and logistic regression models.

Main Results:

  • Patients with a history of KD showed significantly higher PWV compared to controls.
  • No significant difference in ABI was observed between KD patients and controls.
  • PWV and ABI did not differ between KD patients with or without coronary aneurysms.

Conclusions:

  • Individuals with a history of Kawasaki disease may exhibit increased aortic stiffness.
  • Early detection and monitoring of vascular health in KD survivors are important.
Abstract

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