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Accidental tenfold overdose of propofol in a 6-month old infant undergoing elective craniosynostosis repair

B Patermann1, S Buzello, M Dück

  • 1Department of Anaesthesiology, University of Cologne, Joseph-Stelzmann-Str. 9, 50931 Cologne, Germany.

Anaesthesia
|August 18, 2004
PubMed

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Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.