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Updated: Aug 23, 2026
A Novel and Translational Rat Model of Concussion Combining Force and Rotation with In Vivo Cerebral Microdialysis
Published on: July 12, 2019
[The study on expression of NF-kappaB in experimental brain contusion in rats]
Lu-yang Tao1, Xi-ping Chen, Mei Ding
1School of Medicine, Suzhou University, Suzhou 215007, China. luyangtao@suda.edu.cn
Objective:
To investigate the expression of NF-kappaB in different post-traumatic intervals and severity of brain injury.
Methods:
Fifty-four brain tissue samples of slight (n=24), moderate (n=24) brain injury, sham (n=3) and control (n=3) of rat were examined by immunohistochemical staining, westernblot and RT-PCR.
Results:
Up-regulating of NF-kappaB expression was found in tissues from traumatic brain injury compared with controls in early 1 hour after TBI, and reached peak at 24h and 48h and disappeared after 7 days. The expression of NF-kappaB mRNA has association with contusion severity.
Conclusion:
NF-kappaB may benefit to the estimation of posttraumatic intervals of brain injury.
