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Related Experiment Videos

The CD5+ B-cell.

Mariella Dono1, Giannamaria Cerruti, Simona Zupo

  • 1S. C. Oncologia Medica C, Istituto Nazionale per la Ricerca sul Cancro, IST, L.go Rosanna Benzi, n. 10, 16132 Genova, Italy. mariella.dono@istge.it

The International Journal of Biochemistry & Cell Biology
|August 18, 2004
PubMed
Summary
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Research into B-lymphoproliferative disorders focuses on normal follicular mantle B-cells. Increased CD5+ B-cells in the elderly may explain the higher incidence of B-cell chronic lymphocytic leukemia (B-CLL) and mantle cell lymphoma (MCL).

Area of Science:

  • Immunology
  • Hematology
  • Oncology

Background:

  • B-lymphoproliferative disorders are studied by understanding their normal counterparts.
  • Follicular mantle B-cells (CD23+ IgM+ IgD+) surround germinal centers.
  • CD5+ B-cells with follicular mantle (FM) phenotype exhibit specific features.

Purpose of the Study:

  • To elucidate the biology of B-lymphoproliferative disorders.
  • To investigate the role of CD5+ B-cells in disease incidence.
  • To correlate CD5+ B-cell changes with age and specific malignancies.

Main Methods:

  • Phenotypic analysis of B-cell populations.
  • Morphologic and functional characterization of CD5+ B-cells.
  • Age-related B-cell count assessment in humans and mice.

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Main Results:

  • CD5+ B-cells are abundant in fetal life, decrease with age, and increase in the elderly.
  • These cells display a distinct phenotype (CD5+, FM) and functional characteristics (unmutated VH genes, natural antibody production).
  • Increased CD5+ B-cells in the elderly correlate with higher incidence of B-cell chronic lymphocytic leukemia (B-CLL) and mantle cell lymphoma (MCL).

Conclusions:

  • The normal CD5+ B-cell population is a likely origin for B-CLL and MCL.
  • Age-related changes in CD5+ B-cell numbers may predispose individuals to these malignancies.
  • Understanding CD5+ B-cell biology is crucial for B-lymphoproliferative disorder research.