Related Experiment Video

Updated: Jun 9, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

15.9K

Lymphoplasmacyte-rich meningioma with hematologic signs and PD-L1 over-expression

Gabriele Gaggero1, Michela Campora2, Davide Taietti3

  • 1IRCCS Ospedale Policlinico San Martino, Pathology Unit, Genoa, Italy.

Autopsy & Case Reports
|August 23, 2022
PubMed

Insights

Lymphoplasmacyte-rich meningioma (LPRM) is a rare grade I tumor. This case highlights its association with anemia and cognitive decline, offering insights into its immune microenvironment.

Area of Science:

  • Neuropathology
  • Oncology
  • Immunology

Background:

  • Lymphoplasmacyte-rich meningioma (LPRM) is an exceptionally rare variant of grade I meningioma.
  • LPRM can present with significant peripheral blood abnormalities, including anemia and gammopathy, often resolving post-surgery.
  • The rarity of LPRM limits understanding of its origins and behavior.

Purpose of the Study:

  • To document a case of right frontal LPRM in an elderly male presenting with cognitive decline and mild anemia.
  • To investigate the immunomorphological characteristics of LPRM, focusing on PD-L1 expression.
  • To explore the role of the inflammatory tumor microenvironment and immune checkpoints in LPRM.

Main Methods:

  • Case report of a 72-year-old male with right frontal LPRM.
  • Clinical assessment including evaluation of cognitive function and peripheral blood counts.
  • Immunohistochemical analysis to determine the tumor's cellular composition and PD-L1 expression profile.

Main Results:

  • The patient presented with general cognitive decadence and mild anemia.
  • Immunohistochemistry revealed prominent PD-L1 expression in the LPRM.
  • The findings suggest a potential link between the inflammatory microenvironment, PD-L1 expression, and immune checkpoint activity in LPRM.

Conclusions:

  • LPRM, though rare, can be associated with systemic effects like anemia and neurological symptoms.
  • Prominent PD-L1 expression in LPRM warrants further investigation into its immunobiology.
  • Understanding the immune microenvironment of LPRM may offer new therapeutic avenues.
Keywords:
MeningiomaMicroenviromentPD-L1

More Related Videos

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG08:46

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG

Published on: March 7, 2017

17.1K
Author Spotlight: Assessing the Potential of Circulating Tumor Cells in Leptomeningeal Disease Research06:25

Author Spotlight: Assessing the Potential of Circulating Tumor Cells in Leptomeningeal Disease Research

Published on: March 29, 2024

999

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...