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Related Experiment Videos

CT perfusion parameter values in regions of diffusion abnormalities.

Marcello Galvez1, Gerald E York, James D Eastwood

  • 1Department of Radiology/Neuroradiology, Duke University Medical Center, Durham, NC, USA.

AJNR. American Journal of Neuroradiology
|August 18, 2004
PubMed
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Dynamic CT perfusion imaging reveals decreased cerebral blood flow and volume in stroke-affected brain regions identified by diffusion-weighted MRI. This study correlates CT perfusion with diffusion abnormalities in acute ischemic stroke.

Area of Science:

  • Neuroimaging
  • Radiology
  • Cerebrovascular Disease

Background:

  • Dynamic CT perfusion imaging assesses cerebral hemodynamics in ischemia.
  • Understanding CT perfusion in diffusion-abnormal regions is limited.
  • Diffusion-weighted (DW) MRI is key for identifying the ischemic core.

Purpose of the Study:

  • Measure CT-derived perfusion values in acute ischemic lesions.
  • Characterize lesions by increased DW signal intensity and decreased apparent diffusion coefficient (ADC).
  • Compare these perfusion values to contralateral normal brain tissue.

Main Methods:

  • Analyzed 10 patients with acute middle cerebral artery stroke (symptom onset < 8 hours).
  • Patients underwent CT perfusion and DW imaging within 2 hours.

Related Experiment Videos

  • Compared pixel-by-pixel CT perfusion parameters in diffusion-abnormal regions versus normal tissue.

    • Main Results:

    • Significant decreases in cerebral blood flow and volume observed in infarct regions.
    • Elevated mean transit times noted in infarct regions.
    • Perfusion parameters in core infarct regions differed significantly from contralateral normal brain.

    Conclusions:

    • CT perfusion findings correlate with diffusion abnormalities on DW imaging.
    • Decreased cerebral blood flow, mean transit time, and cerebrovascular volume indicate acute ischemia.
    • Provides valuable insights into perfusion changes within diffusion-abnormal areas in acute ischemia.