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[Theophylline release and diffusion from a compressed ethylcellulose matrix through an artificial membrane]
N Noureddine1, W Douki, J-C Chaumeil
1Laboratoire de Pharmacie Galénique, Faculté de Pharmacie de Monastir, Université du Centre, 5000 Monastir, Tunisie.
Annales Pharmaceutiques Francaises
|August 18, 2004
Summary
This study investigated theophylline release from ethylcellulose matrices, finding that dissolution is primarily driven by drug solubility and diffusion. The rate of theophylline release directly impacts its diffusion rate.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Ethylcellulose matrices are utilized for sustained drug release.
- Theophylline is a common bronchodilator requiring controlled release formulations.
Purpose of the Study:
- To investigate theophylline dissolution and diffusion kinetics from ethylcellulose matrices.
- To elucidate the drug release mechanism using the Higuchi model.
- To assess the impact of different media compositions on drug release.
Main Methods:
- Sustained release tablets manufactured via direct compression.
- Dissolution and diffusion studies conducted using an absorption simulator.
- Varied donor compartment media (pH 1.2, 5, 6, with glucose, with amino acids) at pH 7.4 receiver medium.
- Higuchi equation applied to determine the release mechanism.
Main Results:
- Theophylline dissolution is predominantly governed by its solubility.
- The release mechanism follows a diffusion-controlled pathway.
- Diffusion coefficients indicate release is dependent on the rate of theophylline release.
Conclusions:
- Ethylcellulose matrices provide a diffusion-controlled release for theophylline.
- Drug solubility is a key factor influencing theophylline release rate.
- Understanding these parameters is crucial for optimizing sustained-release formulations.