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Updated: Aug 23, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

New development in the treatment of psoriasis--infliximab

Aldona Pietrzak1, Grazyna Chodorowska, Iwona Jazienicka

  • 1Department of Dermatology, Medical University of Lublin.

Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina
|August 19, 2004
PubMed

TNF-alpha may have an impact on principal pathological phenomena in psoriatic skin through inducing inflammatory cells migration from blood vessels. It follows that blockade of TNF-alpha should diminish inflammation and normalize keratinocyte proliferation in psoriasis. Infliximab is a mouse-human chimeric monoclonal antibody that neutralizes the biologic activity of tumor necrosis factor alpha (TNF-alpha) by binding to the soluble and transmembrane forms of this cytokine and inhibiting its binding to the receptors. We present literature data concerning both application of infliximab in patients with psoriasis and its side effects.

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