Related Experiment Video
Updated: Aug 23, 2026
A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds
Published on: February 23, 2024
Treatment of partial-thickness burns: a prospective, randomized trial using Transcyte
Rohit J Kumar1, Roy M Kimble, Robert Boots
1Stuart Pegg Burns Unit, Royal Children's Hospital, Brisbane, Queensland, Australia. rohitjkumar@bigpond.com
Insights
TransCyte significantly accelerated re-epithelialization for pediatric partial-thickness burns compared to Biobrane and Silvazine. This bio-engineered skin substitute also reduced the need for autografting and fewer dressing changes, improving wound healing outcomes.
Area of Science:
- Pediatric Burn Care
- Wound Healing
- Biomaterials in Medicine
Background:
- Partial-thickness burns in children present unique challenges for wound management.
- Evaluating advanced wound dressings is crucial for optimizing healing and minimizing complications.
- Current treatments include bio-engineered skin substitutes and antimicrobial creams.
Purpose of the Study:
- To compare the efficacy of TransCyte, Biobrane, and Silvazine cream in treating pediatric partial-thickness burns.
- To determine the primary endpoint of time to >=90% re-epithelialization.
- To assess secondary outcomes, including autografting requirements and dressing changes.
Main Methods:
- A randomized controlled trial involving 33 pediatric patients with 58 partial-thickness burn wounds.
- Patients were randomized to receive TransCyte, Biobrane, or Silvazine treatment.
- Wound closure was assessed every other day using clinical evaluation and laser Doppler imaging.
Main Results:
- TransCyte demonstrated the fastest mean re-epithelialization time (7.5 days) compared to Biobrane (9.5 days) and Silvazine (11.2 days).
- Fewer wounds required autografting with TransCyte (5%) versus Biobrane (17%) and Silvazine (24%).
- TransCyte also required fewer dressing changes and local wound care interventions.
Conclusions:
- TransCyte is superior to Biobrane and Silvazine for treating partial-thickness burns in children, promoting faster healing.
- The use of TransCyte reduces the need for surgical autografting in pediatric burn patients.
- TransCyte offers a more efficient wound management approach, minimizing patient discomfort and healthcare resource utilization.
Background:
The purpose of the present study was to compare the effectiveness of three burns dressings (TransCyte, a bio-engineered skin substitute; Biobrane; and Silvazine cream (silver sulphadiazine and 0.2% chlorhexidine)), in treating children with partial-thickness burns. The primary objective was to determine the days until > or =90% re-epithelialization. The secondary objectives were to evaluate the number of wounds requiring autografting and the number of dressing changes/local wound care required.
Methods:
Study wounds were identified on each patient and the patients were randomized to receive TransCyte or Biobrane or Silvazine. Assessment of study wound closure began at 2 days after treatment and continued at least every other day thereafter until the wounds re-epithelialized or were autografted. A laser Doppler imaging system was used as an adjunct to assessing the depth of the burn.
Results:
Thirty-three patients with 58 wound sites enrolled in the study (TransCyte, n = 20, Biobrane, n = 17; Silvazine, n = 21). Mean time to re-epithelialization was 7.5 days for TransCyte, 9.5 days for Biobrane, and 11.2 days for Silvazine. The number of wounds requiring autografting were 5/21 (24%) for Silvazine, 3/17 (17%) for Biobrane, and 1/20 (5%) for TransCyte.
Conclusions:
When used in partial-thickness burns in children, TransCyte promotes fastest re-epithelialization and required less overall dressings then Biobrane or Silvazine. Patients who received Silvazine or Biobrane require more autografting than those treated with TransCyte.
Related Concept Videos
01:22Burn Injuries
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
01:11Blinding