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Monocyte function in healthy middle-aged people receiving fermented milk containing Lactobacillus casei.
D Parra1, B Martinez De Morentin, J M Cobo
1Department of Physiology and Nutrition, University of Navarra (Edif. Investigación), C/ Irunlarrea, s/n, 31008 Pamplona, Spain.
The Journal of Nutrition, Health & Aging
|August 19, 2004
Summary
Consuming Lactobacillus casei fermented milk enhanced monocyte oxidative burst capacity in middle-aged adults. This probiotic intervention may support immune function, especially in those with lower baseline activity.
Area of Science:
- Immunology
- Microbiology
- Nutrition Science
Background:
- Lactic acid bacteria are explored for their potential to boost immune system activity.
- Probiotics, including specific strains like Lactobacillus casei, are investigated for immunomodulatory effects.
Purpose of the Study:
- To evaluate the impact of Lactobacillus casei fermented milk on monocyte activity in middle-aged individuals.
- To determine if daily consumption of a probiotic-rich fermented milk influences immune cell function.
Main Methods:
- A randomized controlled trial involving 45 healthy middle-aged volunteers (51-58 years).
- Participants consumed either Lactobacillus casei fermented milk or a placebo daily for 8 weeks.
- Monocyte oxidative burst capacity and white blood cell counts were assessed using flow cytometry.
Main Results:
- No significant changes in immune cell proportions were observed in either group.
- The Lactobacillus casei group showed a significant increase in monocyte oxidative burst capacity (p=0.029).
- This increase was more pronounced in individuals with lower baseline monocyte activity, showing a significant inverse correlation (r=-0.653, p=0.004).
Conclusions:
- Daily intake of Lactobacillus casei fermented milk can modulate monocyte oxidative burst capacity in healthy middle-aged adults.
- The probiotic intervention appears particularly beneficial for individuals with lower initial immune cell activity.
- This dietary strategy shows potential for maintaining immune competence during aging.