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Related Experiment Video

Updated: Jul 12, 2026

Obtaining Specimens with Slowed, Accelerated and Reversed Aging in the Honey Bee Model
10:58

Obtaining Specimens with Slowed, Accelerated and Reversed Aging in the Honey Bee Model

Published on: August 29, 2013

Surgery-associated accelerated biological aging: Evidence from a cross-sectional study.

Xiaoxiao Wang1, Lei Chen2, Kaixi Liu2

  • 1Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China; Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing 100191, China; Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing 100191, China.

The Journal of Nutrition, Health & Aging
|July 9, 2026
PubMed
Summary

Major surgery accelerates biological aging, but physical activity (PA) can mitigate this effect. Optimizing surgical timing and maintaining high PA levels may reduce the aging burden from surgical procedures.

Keywords:
Biological agingPhenoAgeAccelPhysical activitySurgery/anesthesiaUK Biobank

Related Experiment Videos

Last Updated: Jul 12, 2026

Obtaining Specimens with Slowed, Accelerated and Reversed Aging in the Honey Bee Model
10:58

Obtaining Specimens with Slowed, Accelerated and Reversed Aging in the Honey Bee Model

Published on: August 29, 2013

Area of Science:

  • Gerontology and Aging Research
  • Surgical Science
  • Preventive Medicine

Background:

  • Surgery and anesthesia are significant physiological stressors linked to biological aging.
  • Physical activity (PA) is recognized for its anti-aging properties.
  • The interplay between PA and surgery-induced biological aging requires clarification.

Purpose of the Study:

  • To investigate the association between surgical history and biological aging.
  • To determine if physical activity modifies the relationship between surgery and biological aging.

Main Methods:

  • Cross-sectional analysis of UK Biobank data (126,668 participants, aged ≥60).
  • Assessed biological aging using PhenoAge acceleration (PhenoAgeAccel).
  • Examined associations with surgery number, interval, and recency, adjusting for covariates; PA categorized as high (≥600 MET-min/week) or low (<600 MET-min/week).

Main Results:

  • Increased cumulative surgical exposure correlated with accelerated biological aging (PhenoAgeAccel).
  • Participants with ≥4 surgeries showed 0.14–0.39 years of PhenoAgeAccel compared to those with none.
  • Shorter surgical intervals (≤1 year) and recent surgery (≤1 year) were linked to accelerated aging.
  • High PA attenuated these associations, with significant aging observed only at higher surgery counts or within one year of recent surgery.

Conclusions:

  • Surgical factors like number, interval, and recency are associated with accelerated biological aging.
  • Optimizing surgical timing could mitigate the biological burden of repeated surgeries.
  • Higher physical activity levels are negatively correlated with surgery-related aging.