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Continuous solid-phase extraction and preconcentration of bisphenol A in aqueous samples using molecularly imprinted
Blanca San Vicente1, Fernando Navarro Villoslada, María C Moreno-Bondi
1Laboratory of Optical Sensors, Department of Analytical Chemistry, Faculty of Chemistry, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Analytical and Bioanalytical Chemistry
|August 19, 2004
Summary
Chemometric optimization yielded a bisphenol A (BPA) imprinted polymer for selective BPA preconcentration from water. This molecularly imprinted solid-phase extraction (MISPE) method offers high recovery and sensitive detection for environmental monitoring.
Area of Science:
- Environmental Chemistry
- Analytical Chemistry
- Polymer Science
Background:
- Bisphenol A (BPA) is an endocrine-disrupting chemical found in various environmental matrices.
- Effective methods for selective BPA preconcentration and detection are crucial for environmental monitoring.
- Molecularly imprinted polymers (MIPs) offer high selectivity for target analytes.
Purpose of the Study:
- To develop and optimize a molecularly imprinted polymer for selective bisphenol A (BPA) preconcentration.
- To evaluate the chromatographic selectivity of the BPA-imprinted polymer.
- To establish an efficient method for BPA analysis in aqueous samples.
Main Methods:
- Chemometric optimization of a BPA-imprinted polymer composition.
- Preparation of a BPA-imprinted polymer packed column for solid-phase extraction.
- Development of a continuous on-column molecularly imprinted solid-phase extraction (MISPE) procedure.
- HPLC with fluorescence detection for BPA quantification.
Main Results:
- The optimized MIP demonstrated high selectivity for BPA over related compounds.
- The MISPE method achieved >84% recovery for BPA from aqueous samples (10-100 mL volumes).
- Detection and quantification limits were 1.0 and 3.3 ng mL(-1), respectively.
- Analytical recoveries of 92-101% with RSD <5.0% were obtained for spiked river water samples.
Conclusions:
- The developed BPA-imprinted polymer and MISPE method provide a selective and sensitive approach for BPA preconcentration.
- This method is effective for analyzing BPA in complex environmental samples like river water.
- The findings contribute to improved environmental monitoring strategies for endocrine-disrupting chemicals.