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Updated: Aug 23, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
Published on: November 21, 2013
Self-assembly of small peptidomimetic cyclophanes
Jorge Becerril1, M Isabel Burguete, Beatriu Escuder
1Departament de Química Inorgànica i Orgànica, Universitat Jaume I, 12071 Castelló, Spain.
Abstract:
The self-assembly of a series of small peptidomimetic cyclophanes in organic solvents was studied. X-ray diffraction, NMR spectroscopy, and molecular modelling were used to understand the structural features of these self-assembling compounds both at the molecular and supramolecular level. The factors that could influence the formation of gels rather than crystals were studied and a model for the arrangement of molecules in the gel was proposed. Furthermore, scanning electron microscopy revealed that in some cases these compounds undergo a transcription of chirality when going from organogelator to helicoidal gel fibres.
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