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Pyrene-Functionalized Bioinspired (L/D) Amino Acids for Nanoassembly Modulations and Intracellular Cu(II) Detection.

Tarkeshwar Maddeshiya1, Praveen Kumar2, Neha Garg2

  • 1Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, India.

Chempluschem
|March 29, 2026
PubMed
Summary
This summary is machine-generated.

Researchers created new bioinspired materials using amino acids and a pyrene fluorophore. These materials exhibit nanoassembly and can detect copper ions within cells, paving the way for advanced nanoarchitecture applications.

Keywords:
bioinspired materialschiroptical propertiesnanoarchitecturepyrene flurophore

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Area of Science:

  • Materials Science
  • Biochemistry
  • Nanotechnology

Background:

  • Bioinspired materials offer unique properties for advanced applications.
  • Chiral amino acids can impart specific functionalities to synthetic materials.
  • Pyrene fluorophores are useful for optical sensing and imaging.

Purpose of the Study:

  • To synthesize novel bioinspired materials incorporating chiral amino acids and a pyrene fluorophore.
  • To investigate the chiroptical properties and nanoassembly behavior of these materials.
  • To explore their potential for intracellular copper(II) ion detection.

Main Methods:

  • Synthesis of two bioinspired materials using L/D-valine and L/D-phenylalanine with a pyrene fluorophore.
  • Chiroptical property analysis using circular dichroism spectroscopy.
  • Evaluation of nanoassembled modulation and intracellular copper(II) detection capabilities.

Main Results:

  • Successful synthesis of two distinct bioinspired materials.
  • Demonstration of nanoassembled modulation in the synthesized materials.
  • Evidence of intracellular copper(II) ion detection using these materials.
  • Characterization of unique chiroptical properties.

Conclusions:

  • The developed bioinspired materials exhibit promising nanoassembly and sensing capabilities.
  • This work provides a viable strategy for designing advanced bioinspired materials.
  • Potential applications in nanoarchitecture and biological sensing are highlighted.