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Successful discontinuation of secondary prophylaxis for histoplasmosis after highly active antiretroviral therapy

Hsin-Yun Sun1, Mao-Yuan Chen, Szu-Min Hsieh

  • 1Department of Internal Medicine, National Taiwan University Hospital, Taipei.

Journal of the Formosan Medical Association = Taiwan Yi Zhi
|August 20, 2004
PubMed

Whether maintenance antifungal prophylaxis against histoplasmosis should be continued life-long in patients with immune restoration after highly active antiretroviral therapy (HAART) remains unclear. We report a case of disseminated histoplasmosis involving the skin, lung, gastrointestinal tract, mesentery, and retroperitoneum in a 33-year-old man with acquired immunodeficiency syndrome. His symptoms improved after use of amphotericin B and itraconazole in addition to ileostomy to relieve the intestinal obstruction. After the start of HAART, he was able to discontinue itraconazole as maintenance therapy without relapse for 24 months.

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