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Human caliciviruses as a cause of severe gastroenteritis in Peruvian children

Umesh D Parashar1, Jin-Fen Li, Rosa Cama

  • 1Respiratory and Enteric Viruses Branch, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA. uap2@cdc.gov

The Journal of Infectious Diseases
|August 21, 2004
PubMed

Insights

Human caliciviruses (HuCVs) are a significant cause of severe childhood gastroenteritis in Peru. Studies show HuCVs were more prevalent in sick children than in healthy controls, indicating their role in illness.

Area of Science:

  • Pediatric Gastroenterology
  • Virology
  • Public Health

Background:

  • Gastroenteritis is a leading cause of childhood illness globally.
  • The specific role of human caliciviruses (HuCVs) in severe pediatric gastroenteritis requires further definition.

Purpose of the Study:

  • To investigate the prevalence and role of HuCVs in Peruvian children hospitalized with severe gastroenteritis.

Main Methods:

  • Fecal and serum samples were collected from 233 hospitalized children with gastroenteritis (case patients) and 248 healthy children (control subjects).
  • HuCV infection was detected using fecal and serological testing.

Main Results:

  • Human calicivirus infection was detected in 55% of case patients, significantly higher than in control subjects (35% vs. 13%).
  • HuCV infection was more common in children with gastroenteritis without other identified pathogens (77%) compared to those with coinfections (49%).

Conclusions:

  • Human caliciviruses are a significant etiological agent in severe gastroenteritis among Peruvian children.
  • HuCVs play a crucial role in pediatric gastroenteritis, particularly in cases without other identifiable infectious agents.

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