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Bone marrow reconstitution as a relevant model of genetically programmed leukemia
A Dolnikov1, S Shen, T Passioura
1Children's Cancer Institute Australia, Kensington, New South Wales, Australia. adolniko@MEDAU.JNJ.com
Abstract:
Mouse model systems which allow bone marrow reconstitution can be used to analyse genetically programmed leukemia. The original and most widely used system is that of post 5-fluorouracil mouse hematopoietic stem cells (HSC) into lethally irradiated syngeneic mice. Another more recent system allows analysis of human HSCs in the NOD-SCID mouse. Both systems are discussed as models for analysis of gene induced leukemia.
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