Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diabetic cardiomyopathy: electromechanical cellular alterations.

O Casis1, E Echevarria

  • 1Department of Physiology, School of Pharmacy, University of the Basque Country, P.O. Box 699, 48080 Bilbao, Spain. ofpcasao@lg.ehu.es

Current Vascular Pharmacology
|August 24, 2004
PubMed
Summary

Diabetic cardiomyopathy, a complication of diabetes mellitus, involves cardiac arrhythmias and sudden death. Research suggests altered cardiac ionic currents and impaired autonomic regulation contribute to its development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relationship Between Fibrinogen-to-Albumin Ratio and Pre-Eclampsia: A Retrospective Cohort Study.

Pregnancy hypertension·2026
Same author

A randomised controlled trial of a program based on the theory of planned behavior to promote fruit and vegetable intake among schoolchildren: PROFRUVE study protocol.

BMC public health·2018
Same author

Sex differences in the aging pattern of renin-angiotensin system serum peptidases.

Biology of sex differences·2017
Same author

Dysautonomia Differentially Influences the Effect of Affective Pain Perception on Quality of Life in Parkinson's Disease Patients.

Parkinson's disease·2016
Same author

Thyroid stimulating hormone directly modulates cardiac electrical activity.

Journal of molecular and cellular cardiology·2015
Same author

Basolateral expression of GRP94 in parietal cells of gastric mucosa.

Biochemistry. Biokhimiia·2014

Area of Science:

  • Cardiology
  • Diabetology
  • Electrophysiology

Background:

  • Diabetic patients exhibit increased cardiac arrhythmias and mortality.
  • Diabetic cardiomyopathy's physiological basis remains incompletely understood.
  • Electrocardiogram (ECG) alterations, particularly in QT interval and T wave, are common in diabetics.

Purpose of the Study:

  • To elucidate the underlying physiological mechanisms of diabetic cardiomyopathy.
  • To identify key alterations in cardiac ionic currents and regulatory factors.

Main Methods:

  • Analysis of cardiac ionic currents in myocytes from diabetic hearts.
  • Investigation of metabolic alterations within cardiac myocytes.
  • Evaluation of extra-cardiac factors, including autonomic neuropathy and trophic factors.

Related Experiment Videos

Main Results:

  • Reduced potassium repolarizing currents observed in diabetic myocytes.
  • Impaired protein kinase/phosphatase activity, pH, and calcium handling.
  • Diminished noradrenaline release due to diabetic autonomic neuropathy.
  • Reduced myocyte response to noradrenaline and altered trophic factor support.

Conclusions:

  • Diabetic cardiomyopathy arises from complex physiopathological mechanisms.
  • Direct metabolic myocyte changes and impaired neuro-hormonal regulation are implicated.
  • Further research is crucial for prevention and improved pharmacological management.