Related Experiment Videos
[Contact factors in severe sepsis]
1Laboratoire d'Immuno-Hématologie, Hôpital Lariboisière, Paris.
Presse Medicale (Paris, France : 1983)
|February 8, 1992
Summary
Severe sepsis activates the kininogen-kinin pathway and contact system, impacting hemodynamics and coagulation. Targeting this pathway with protease inhibitors may offer therapeutic benefits.
Area of Science:
- Biochemistry
- Hematology
- Immunology
Context:
- Coagulation and fibrinolysis are complex systems with interrelations to the kininogen-kinin and complement pathways.
- Severe sepsis involves microbial substances like lipopolysaccharides activating the contact system.
- Contact activation is implicated in the hemodynamic changes and consumption coagulopathy seen in severe sepsis.
Purpose:
- To explore the interrelations between coagulation, fibrinolysis, kininogen-kinin pathway, and complement.
- To investigate the role of contact activation in severe sepsis-induced hemodynamic changes and consumption coagulopathy.
- To assess the potential for therapeutic interventions targeting the kininogen-kinin pathway in severe sepsis.
Summary:
- The study highlights that coagulation and fibrinolysis are not isolated but interconnected with the kininogen-kinin and complement systems.
- In severe sepsis, lipopolysaccharides can trigger the contact system, contributing to hemodynamic instability and coagulopathy.
- Evidence of kininogen-kinin pathway activation in sepsis patients suggests potential therapeutic targets.
Impact:
- Understanding these complex interactions is crucial for managing severe sepsis.
- Identifying kininogen-kinin pathway activation provides a basis for developing novel therapeutic strategies.
- The findings suggest that protease inhibitors could be valuable in treating sepsis-related complications.