Related Experiment Videos
Parturition and angioneurotic oedema
C Marescal1, A S Ducloy-Bouthors, J Laurent
1Department of Anesthesiology, Hôpital Jeanne de Flandre C.H.R.U. 2, Avenue O. Lambret, 59037 Lille, France.
International Journal of Obstetric Anesthesia
|August 24, 2004
Summary
Hereditary and acquired angioneurotic oedema during pregnancy can be managed with specific therapies. Successful vaginal delivery under epidural analgesia was achieved in two cases, demonstrating effective management strategies.
Area of Science:
- Immunology
- Obstetrics
- Genetics
Background:
- Angioneurotic oedema is a rare condition linked to C1 esterase inhibitor deficiency.
- Hereditary angioneurotic oedema presents as type I or type II deficiency.
- Acquired angioneurotic oedema can result from antibodies targeting C1 esterase inhibitor.
Purpose of the Study:
- To discuss management strategies for angioneurotic oedema during pregnancy.
- To highlight prophylactic treatments based on fetal sex.
- To present successful delivery outcomes in pregnant patients with angioneurotic oedema.
Main Methods:
- Review of prophylactic treatments including danazol and epsilon aminocaproic acid.
- Discussion of management for acquired angioneurotic oedema with corticosteroids.
- Case presentations of hereditary and acquired angioneurotic oedema managed with epidural analgesia during labor.
Main Results:
- Prophylactic treatment can mitigate acute attacks during pregnancy and postpartum.
- Regional analgesia is recommended for labor and delivery to prevent complications.
- Successful vaginal delivery under epidural analgesia was achieved in both presented cases.
Conclusions:
- Effective management strategies exist for angioneurotic oedema in pregnancy.
- Individualized treatment based on hereditary or acquired forms and fetal sex is crucial.
- Epidural analgesia provides a safe and effective option for labor and delivery in these patients.