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Updated: Aug 22, 2026

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
Published on: March 10, 2021
Characterization and evolution of major histocompatibility complex class II genes in the aye-aye, Daubentonia
Yasuhiro Go1, Gilbert Rakotoarisoa, Yoshi Kawamoto
1Department of Biosystems Science, The Graduate University for Advanced Studies (Sokendai), Hayama, Kanagawa, 240-0193, Japan. go_yasuhiro@soken.ac.jp
Abstract:
Major histocompatibility complex genes (Mhc-DQB and Mhc-DRB) were sequenced in seven aye-ayes (Daubentonia madagascariecsis), which is an endemic and endangered species in Madagascar. An aye-aye from a north-eastern population showed genetic relatedness to individuals of a north-western population and had a somewhat different repertoire from another north-eastern individual. These observations suggest that the extent of genetic variation in Mhc genes is not excessively small in the aye-aye in spite of recent rapid destruction of their habitat by human activities. In light of Mhc gene evolution, trans-species and allelic polymorphisms can be estimated to have been retained for more than 50 Ma (million years) based on the time scale of lemur evolution.
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