[A new procedure in making reliable experimental models of gastroesophageal reflux]

To provide a reliable experimental model for gastroesophageal reflux (GER) study.

Twenty Japan 5-month-old male rabbits were randomly divided into two groups: group cardiomyotomy (n=10), group partial cardiomyectomy (n=10). The operations of cardiomyotomy and parital cardiomyectomy were performed in 2 groups respectively. All the animals underwent intraesophageal pH detection 1 week before operation and 4 weeks after operation. The mean changes of reflux ratios were compared between before operation and after operation.

In gastroesophageal reflux ratio between before operation and after operation, there was no significant difference in group cardiomyotomy (1.98%+/-1.52% and 4.32%+/-2.39%, P>0.05) and there was significant difference in group partial cardiomyectomy (1.56%+/-1.57% and 13.56%+/-3.27%, P<0.05).

The reliable experimental model of GER can be made with procedure of partial cardiomyectomy. It can be used in estimating the operative procedure of anti-reflux and is conducive to dynamic observation and study of esophagitis.