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Updated: Aug 20, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
Reactive perforating collagenosis associated with scabies in a diabetic
T Brinkmeier1, R A Herbst, P J Frosch
1Department of Dermatology, Klinikum Dortmund gGmbH, and University of Witten/Herdecke, Beurhausstrasse 40, D-44137 Dortmund, Germany. t.brinkmeier@derma.de
Abstract:
Reactive perforating collagenosis (RPC) in adults commonly manifests in patients with diabetes mellitus. Pruritus and consequent induced scratching have been identified as the bases for the evolution of this skin disease. We present the unusual case of a 55-year-old female diabetic with characteristic umbilicated skin lesions and a long history of scabies. Histology from a crusty nodule revealed transepidermal elimination of collagen. Following antiscabietic treatment, two courses of oral doxycycline demonstrated beneficial effects in controlling the perforating skin disorder.
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