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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Metastasis02:30

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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[Histamine intolerance mimics anorexia nervosa].

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Related Experiment Video

Updated: Mar 29, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
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A 3D Organotypic Melanoma Spheroid Skin Model

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[Metastasized occult melanomas?].

I Kellner1, R A Herbst2

  • 1Klinik für Hautkrankheiten und Allergologie, HELIOS Hauttumorzentrum Erfurt, HELIOS Klinikum Erfurt GmbH, Nordhäuser Straße 74, 99869, Erfurt, Deutschland. ivonne.kellner@helios-kliniken.de.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|November 26, 2015
PubMed
Summary
This summary is machine-generated.

Thorough clinical examinations can help diagnose metastasized occult melanoma, even when initial diagnostics are inconclusive. This approach can revise diagnoses in patients with advanced melanoma of unknown primary.

Keywords:
Basic diagnostic workupHistologyMucous membranePhysical examinationSearch for primary

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Area of Science:

  • Dermatology
  • Oncology

Background:

  • Melanoma of unknown primary (MUP) presents a diagnostic challenge.
  • Advanced staging often prompts extensive investigations to locate the primary tumor.

Observation:

  • Two cases of suspected MUP with advanced stage III and IV disease were re-evaluated.
  • A 60-year-old man had a subtle nail plate change and proximal nail fold tumor.
  • A 60-year-old woman presented with a small, non-pigmented labial tumor.

Findings:

  • Histological diagnosis revealed ulcerated acrolentiginous melanoma in the man.
  • Histological diagnosis confirmed nodular mucosal melanoma in the woman.
  • Both primary tumors were initially overlooked due to their subtle or hidden nature.

Implications:

  • Repeated and thorough clinical examinations are crucial for accurate diagnosis in suspected MUP.
  • Current guidelines may not fully capture the value of meticulous clinical assessment in MUP.
  • This highlights the importance of clinical vigilance over extensive, potentially unnecessary, diagnostic procedures.