Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Creation of the necessary analytical quality for generating and using reference intervals.

Gerhard Klein1, Wolfgang Junge

  • 1Roche Diagnostics GmbH, Mannheim, Germany. Gerhard.Klein@Roche.com

Clinical Chemistry and Laboratory Medicine
|August 26, 2004
PubMed
Summary

Establishing reliable laboratory medicine reference intervals requires stringent analytical quality. This involves ensuring precision, accuracy, and stability of diagnostic kits across different instruments for accurate patient results.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Determination of Body Parts in Holstein Friesian Cows Comparing Neural Networks and k Nearest Neighbour Classification.

Animals : an open access journal from MDPI·2021
Same author

Structural Asymmetry and Kinetic Limping of Single Rotary F-ATP Synthases.

Molecules (Basel, Switzerland)·2019
Same author

Oxygenic photosynthesis: history, status and perspective.

Quarterly reviews of biophysics·2019
Same author

The Phylogenetic Signature Underlying ATP Synthase c-Ring Compliance.

Biophysical journal·2015
Same author

Feasibility of automated body trait determination using the SR4K time-of-flight camera in cow barns.

SpringerPlus·2015
Same author

Quantification of the effects of fur, fur color, and velocity on Time-Of-Flight technology in dairy production.

SpringerPlus·2015

Area of Science:

  • Laboratory Medicine
  • Clinical Chemistry
  • Diagnostic Assays

Background:

  • Reference intervals are crucial for interpreting laboratory test results.
  • Analytical quality is a prerequisite for establishing and utilizing reliable reference intervals.
  • Diagnostic kits and their application on various instruments are key components of laboratory testing.

Purpose of the Study:

  • To outline the criteria for analytical quality essential for reference intervals.
  • To differentiate and discuss factors affecting the quality of laboratory methods and their long-term use.
  • To clarify the shared responsibility between manufacturers and users in maintaining analytical quality.

Main Methods:

  • Compilation of criteria for analytical quality in laboratory medicine.

Related Experiment Videos

  • Discussion of factors influencing method and performance quality of diagnostic kits.
  • Examination of factors affecting long-term use quality of laboratory methods.

    • Main Results:

    • Analytical quality is defined by precision, accuracy, and long-term stability of laboratory methods.
    • Quality is categorized into method/performance quality and long-term use quality.
    • Shared responsibility exists between diagnostic kit manufacturers and users for maintaining quality.

    Conclusions:

    • Manufacturers must provide method descriptions and traceability.
    • Users must account for physiological, biometrical, preanalytical, and analytical influences.
    • Adherence to these criteria ensures the integrity and utility of reference intervals.