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Updated: Aug 22, 2026

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice
Published on: November 2, 2019
Development and evaluation of a new apparatus for lymph drainage: preliminary results
J M Pereira de Godoy1, M de Fátima Guerreiro Godoy
1Department of Cardiology and Vascular Surgery, São José do Rio Preto University School of Medicine, São Paulo, Brazil. godoyjmp@riopreto.com.br
Abstract:
Due to the lack of a specific treatment apparatus that enhances lymph flow, we developed a simple, easy-to-use, portable device for patients presenting with lower extremity lymphedema. The aims of the present study were to demonstrate the design and operation of the equipment and to test its efficacy. The new apparatus encourages articulation of the ankle and contraction of the muscles of the calves and feet. Eight patients with clinically diagnosed primary or secondary lymphedema were imaged by lymphscintigraphy before and after one week of using the apparatus. The images were evaluated by two experienced nuclear medicine physicians blinded to the other's results. An improvement in the lymphscintigram images was seen in all patients evaluated. This preliminary study suggests that the new apparatus was easily tolerated, enhanced lymph flow as assessed by lymphscintigraphy, and may have benefits as an adjunctive treatment. Further clinical studies are necessary to fully evaluate its use.

