Related Experiment Video
Updated: Aug 14, 2026

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis
Published on: December 21, 2014
Functional significance of vascular endothelial growth factor and its receptor (receptor-1) in various lung cancer
Nevin Ilhan1, Necip Ilhan, Figen Deveci
1Department of Biochemistry and Clinical Biochemistry, Firat University, Elazig, Turkey. drnilhan@yahoo.com
Objectives:
VEGF is one of the key factors in tumor angiogenesis that may be involved in tumor growth and metastasis. VEGF receptor, a naturally occurring soluble form of the VEGFR-1 (sVEGFR-1. flt-1), is produced by endothelial cells by differential splicing of the flt-1 gene, and is a negative counterpart of the VEGF signaling pathway.
Design And Methods:
We investigated the levels of VEGF and sVEGFR-1, a known intrinsic inhibitor of VEGF, in 42 patients with various types of lung cancers before beginning treatment and 18 healthy subjects.
Results:
Serum sVEGFR-1 levels (mean +/- SD; pg/ml) were 465.17 +/- 158.34 in patients and were significantly higher than those of the healthy subjects (156.39 +/- 89.17) (P < 0.0001). Serum VEGF levels of patients (449.48 +/- 175.54 pg/ml) were significantly higher in patients than in healthy subjects (77.06 +/- 47.26 pg/ml) (P < 0.0001).
Conclusions:
We conclude that increased sVEGFR-1 and VEGF levels are important parameters in lung cancers.
More Related Videos
Related Concept Videos
Mitogens and the Cell Cycle
The Tumor Microenvironment
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Receptor Downregulation in MVBs
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR activation may...
Mechanism of Angiogenesis
Regulation of Angiogenesis and Blood Supply

