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Updated: Aug 11, 2026

Visualization of Endoplasmic Reticulum Localized mRNAs in Mammalian Cells
Published on: December 17, 2012
[RNA localization in the cytoplasm]
Eugenia Basyuk1, Brigitte Lavoie, Rémy Bordonné
1IGMM-CNRS UMR 5535, Université Montpellier II, IFR 122, 1919, route de Mende, 34293 Montpellier Cedex 5, France.
Abstract:
RNA localization in subcytoplasmic areas is a process known for more than twenty years, and more than a hundred RNAs have now been shown to be spatially regulated. In most cases, RNA localization is involved in cell polarity, either by reading spatial clues and translating them into a spatial regulation of gene expression, or more directly by controlling cytoskeletal polarity. In this review, the various functions of RNA localization will be presented, and by analyzing two examples, Ash1 mRNA in yeast and retroviral genomic RNAs in mammals, the reader will be taken step by step into the detailed mechanisms of this fascinating process.
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