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Related Experiment Videos

Diffuse growth pattern affects E-cadherin expression in invasive breast cancer.

Ulrich Brinck1, Susanne Jacobs, Michael Neuss

  • 1Department of Gastroenteropathology, Georg August University of Göttingen, 37099 Göttingen, Germany.

Anticancer Research
|August 28, 2004
PubMed
Summary

Loss of E-cadherin expression correlates with diffuse growth patterns in invasive breast cancer. This association explains the tendency for lower E-cadherin levels in lobular compared to ductal carcinomas.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Pathology

Background:

  • E-cadherin is crucial for cell adhesion in epithelial tissues.
  • Altered E-cadherin expression is implicated in various cancers, including breast cancer.
  • Breast cancer subtypes, lobular and ductal carcinomas, exhibit distinct histological and molecular features.

Purpose of the Study:

  • To investigate the relationship between growth patterns (diffuse vs. compact) and E-cadherin expression in invasive lobular and ductal breast carcinomas.
  • To determine if mutations in exons 6-10 of the E-cadherin gene correlate with growth patterns or expression levels.
  • To understand the contribution of growth patterns to observed differences in E-cadherin expression between lobular and ductal breast cancers.

Main Methods:

  • Immunohistochemistry was used to assess E-cadherin expression.

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  • Polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) was employed to detect mutations in E-cadherin gene exons 6-10.
  • Analysis was performed on 79 cases of invasive lobular and ductal breast cancer.

    • Main Results:

    • E-cadherin expression showed a trend towards being lower in lobular carcinomas compared to ductal carcinomas (p=0.064).
    • Diffuse growth patterns predominated in 60% of lobular carcinomas, while compact growth patterns were more common in 72% of ductal carcinomas.
    • E-cadherin expression was significantly lower in diffuse tumor areas compared to compact areas (p<0.001).
    • No mutations were detected in the analyzed exons of the E-cadherin gene.

    Conclusions:

    • Loss of E-cadherin expression is associated with an increased prevalence of diffuse growth patterns in both lobular and ductal breast cancers.
    • The differing proportions of diffuse and compact growth patterns between lobular and ductal types contribute to the tendency for lower E-cadherin expression in lobular carcinomas.
    • E-cadherin gene mutations in exons 6-10 were not found to be a factor in this study's cohort.