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Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

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Related Experiment Video

Updated: Jun 26, 2026

Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement
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Published on: January 20, 2022

Prognostic Performance of a Modified TRI-SCORE Incorporating RV-PA Uncoupling After Transcatheter Tricuspid Valve

Mhd Nawar Alachkar1,2, Johannes Schlegl1,2, Marwin Bannehr1,2

  • 1Department of Cardiology, University Hospital Heart Center Brandenburg, 16321 Bernau bei Berlin, Germany.

Journal of Cardiovascular Development and Disease
|June 25, 2026
PubMed
Summary
This summary is machine-generated.

Modifying the TRI-SCORE using right ventricular-pulmonary arterial (RV-PA) uncoupling did not enhance its ability to predict mortality in patients undergoing transcatheter tricuspid valve interventions (TTVI). The original and modified scores showed similar prognostic performance.

Keywords:
RV-PA couplingTRI-SCOREtricuspid valve intervention

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Published on: October 16, 2021

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Interventional Cardiology

Background:

  • The TRI-SCORE predicts mortality after tricuspid valve surgery and is valuable in transcatheter tricuspid valve interventions (TTVI).
  • Right ventricular-pulmonary arterial (RV-PA) uncoupling (TAPSE/sPAP ratio) is a potential prognostic marker, but its added value to existing scores is unknown.

Purpose of the Study:

  • To evaluate the incremental prognostic value of RV-PA uncoupling within the TRI-SCORE in patients undergoing TTVI.
  • To compare the prognostic performance of an original TRI-SCORE with a modified version incorporating RV-PA uncoupling.

Main Methods:

  • Prospective cohort study of 109 patients undergoing TTVI.
  • Calculated original TRI-SCORE and a modified TRI-SCORE using RV-PA uncoupling (TAPSE/sPAP <0.406).
  • Assessed 12-month all-cause mortality and a combined endpoint of death or cardiovascular rehospitalization.

Main Results:

  • At 12 months, all-cause mortality was 19.3% and the combined endpoint occurred in 40.4% of patients.
  • Both original and modified TRI-SCOREs significantly predicted 12-month mortality and the combined endpoint.
  • The modified TRI-SCORE, incorporating RV-PA uncoupling, did not demonstrate improved discrimination or prognostic performance compared to the original TRI-SCORE.

Conclusions:

  • Replacing TAPSE with RV-PA uncoupling in the TRI-SCORE did not enhance its prognostic accuracy for mortality or combined outcomes in TTVI patients.
  • The current TRI-SCORE remains a valuable tool for risk stratification in this population.