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Updated: Aug 22, 2026

Imaging of In Situ Interferon Gamma Production in the Mouse Spleen following Listeria monocytogenes Infection
Published on: July 16, 2019
Somatostatin controls LFA-1 gene expression by altering neuraminidase expression in spleen cells
Won-Kee Yoon1, Ho-Jun Kim, Hwa-Young Son
1Biopotency Evaluation Laboratory, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 305-333, Korea.
Abstract:
This study investigated whether neuraminidase (Neu) affects LFA-1 mRNA expression in spleen cells and whether somatostatin (SOM) and substance P (SP) treatment induce changes in the Neu mRNA expression level in spleen cells. Neu treatments down-regulated the LFA-1 mRNA levels after culturing for 2 h. SOM increased the Neu mRNA level slightly after 24-h culture and strongly after 48-h culture. These results suggest that prolonged exposure to SOM may regulate the Neu activation pathway, which in turn impairs the regulation of LFA-1 expression.
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